Journal article
Effects of duloxetine treatment on brain response to painful stimulation in major depressive disorder
M López-Solà, J Pujol, R Hernández-Ribas, BJ Harrison, O Contreras-Rodríguez, C Soriano-Mas, J Deus, H Ortiz, JM Menchón, J Vallejo, N Cardoner
Neuropsychopharmacology | Published : 2010
DOI: 10.1038/npp.2010.108
Abstract
Major depressive disorder (MDD) is characterized by a constellation of affective, cognitive, and somatic symptoms associated with functional abnormalities in relevant brain systems. Painful stimuli are primarily stressful and can trigger consistent responses in brain regions highly overlapping with the regions altered in MDD patients. Duloxetine has proven to be effective in treating both core emotional symptoms and somatic complaints in depression. This study aimed to assess the effects of duloxetine treatment on brain response to painful stimulation in MDD patients. A total of 13 patients and a reference group of 20 healthy subjects were assessed on three occasions (baseline, treatment wee..
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Grants
Awarded by Instituto de Salud Carlos III
Funding Acknowledgements
M Lopez-Sola was supported by Grant number AP2005-0408 of the Spanish Ministry of Education and Science. M Lopez-Sola and J Deus are part of the Research Group SGR 1450 of the Agency of University and Research Funding Management of the Catalan Government. Dr Harrison was supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (ID 628509) and an establishment grant from The Clive and Vera Ramaciotti Foundation. O Contreras-Rodriguez was supported by Grant number RECO-DE2007I054 from the Spanish Ministry of Health. This work received a Grant from Boehringer Ingelheim Spain and Grant number SAF2007-62376 from the Spanish Ministry of Education and Science. All the income from Boehringer Ingelheim was used to cover part of setting and MRI expenses. None of the funding institutions had any further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. Marina Lopez-Sola declares that she has received funding from the University of Barcelona. Dr Jesus Pujol declares that he has received funding from the Institut d'Alta Tecnologia-PRBB, CRC Hospital del Mar. Dr Rosa Hernandez-Ribas declares that she has received funding from the Bellvitge University Hospital-IDIBELL and from the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III, Centro de Investigacion en Red de Salud Mental (CIBERSAM). Dr Ben J Harrison declares that he has received funding from the National Health and Medical Research Council of Australia. Oren Contreras-Rodriguez declares she has received funding from the Fundacio IMIM. Dr Carles Soriano-Mas declares that he has received funding from the Institut d'Alta Tecnologia-PRBB, CRC Hospital del Mar, and from the Fundacio IMIM. Dr Joan Deus declares that he has received funding from the Autonomous University of Barcelona. Hector Ortiz declares that he has received funding from the Technical University of Catalonia and from the General Electric Company. Dr Jose M Menchon declares that he has received funding from the University of Barcelona, the Bellvitge University Hospital-IDIBELL, and from the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III, Centro de Investigacion en Red de Salud Mental (CIBERSAM). He has also received honoraria as a consultant from Almirall, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Lundbeck, and Wyeth. Dr Narcis Cardoner declares that he has received funding from the University of Barcelona, Bellvitge University Hospital-IDIBELL, and from the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III, Centro de Investigacion en Red de Salud Mental (CIBERSAM). He has also received honoraria as a consultant from Almirall, Boehringer Ingelheim, Eli Lilly, Janssen, Lundbeck, Pfizer, and Wyeth. Dr Julio Vallejo declares that he has received funding from the University of Barcelona, the Bellvitge University Hospital-IDIBELL, and from the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III, Centro de Investigacion en Red de Salud Mental (CIBERSAM).